significant new activityopinion, is significantly greater than the quantity or concentration of the living organism that previously entered or was released into the environment; or(b)the entry or release of the living organism into the environment or the exposure or potential exposure of the environment to the living organism in a manner and circumstances that, in the Ministers’ opinion, are significantly different from the manner and circumstances in which the living organism previously entered or was released into the environment or of any previous exposure or potential exposure of the environment to the living organism. (nouvelle activité)