law://eu/reg/2012/231/anx_1__grp_217@2026-11-12| Synonyms | Cellulose hydroxypropyl ether, low substituted |
| Definition | L-HPC is a low-substituted poly (hydroxypropyl) ether of cellulose.L-HPC is manufactured by partial etherification of the anhydroglucose units of pure cellulose (wood pulp) with propylene oxide/hydroxypropyl groups. The resulting product is then purified, dried and milled to yield low-substituted hydroxypropyl cellulose.L-HPC contains not less than 5,0 % and not more than 16,0 % of hydroxypropoxy groups, calculated on the dried basis.L-HPC differs from hydroxypropyl cellulose (E 463) with respect to the degree of molar substitution with hydroxypropoxy groups of the glucose ring unit (0,2 for L-HPC vs 3,5 for E 463) of the cellulose backbone. |
| IUPAC name | Cellulose, 2-hydroxypropyl ether (low substituted) |
| CAS number | 9004-64-2 |
| Einecs | 618-388-0 |
| Chemical name | Hydroxypropyl ether of cellulose, low-substituted |
| Chemical formula | The polymers contain substituted anhydroglucose units with the following general formula:C6H7O2(OR1)(OR2)(OR3)where R1, R2, R3 each may be one of the following:HCH2CHOHCH3CH2CHO(CH2CHOHCH3)CH3CH2CHO[CH2CHO(CH2CHOHCH3)CH3]CH3 |
| Molecular weight | From about 30000 to 150000 g/mol |
| Assay | The average number of hydroxypropoxy groups(–OCH2CHOHCH3) corresponds to 0,2 hydroxypropyl groups per anhydroglucose unit on the anhydrous basis |
| Particle size | by laser diffraction method — Not less than 45 μm (not more than 1 % in weight of particles of less than 45 μm) and not more than 65 μmby size-exclusion chromatography (SEC) — Average (D50) particle size between 47,3 μm and 50,3 μm; D90 value (90 % below given value) between 126,2 μm and 138 μm |
| Description | Slightly hygroscopic white or slightly yellowish or greyish odourless and tasteless, granular or fibrous powder |
| Identification | Passes test |
| Solubility | Insoluble in water; swelling in water. It dissolves in a solution of 10 % sodium hydroxide producing a viscous solution. |
| Assay | Determination of the degree of molar substitution by gas chromatography |
| pH | Not less than 5,0 and not more than 7,5 (1 % colloidal dispersion) |
| Purity | |
| Loss on drying | Not more than 5,0 % (105 °C, 1 hour) |
| Residue on ignition | Not more than 0,8 % determined at 800 °C ± 25 °C |
| Propylene chlorohydrins | Not more than 0,1 mg/kg (on an anhydrous basis) (gas chromatography–mass spectrometry (GC–MS)) |
| Arsenic | Not more than 0,5 mg/kg |
| Lead | Not more than 0,5 mg/kg |
| Mercury | Not more than 0,5 mg/kg |
| Cadmium | Not more than 0,15 mg/kg |
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