(3)In order to keep Regulation (EC) No 440/2008 up to date with technical progress and to reduce the number of animals used for experimental purposes, also in accordance with Directive 2010/63/EU of the European Parliament and of the Councilnote, the Annex of Regulation (EC) No 440/2008 should be reviewed with three updated test methods for the determination of effects on human health, relating to in vitro tests for serious eye damage/eye irritation and skin sensitisationnote, and by adding three new test methods for the assessment of ecotoxicitynote.
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