(3)In order to keep Regulation (EC) No 440/2008 up to date with technical progress and to reduce the number of animals used for experimental purposes, also in accordance with Directive 2010/63/EU of the European Parliament and of the Councilnote, seven test methods should be added to the Annex of Regulation (EC) No 440/2008: one new test method for basic physicochemical propertiesnote, one new and two updated test methods for the determination of effects on human health, relating to in vitro tests for immunotoxicity and skin sensitisationnote, and three updated test methods for the assessment of ecotoxicitynote.
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