law://eu/reg/2013/469/anx_1@2026-11-13| Identification number of the additive | Name of the holder of authorisation | Additive | Composition, chemical formula, description, analytical method | Species or category of animal | Maximum age | Minimum content | Maximum content | Other provisions | End of period of authorisation |
|---|---|---|---|---|---|---|---|---|---|
| mg/kg of complete feedingstuff with a moisture content of 12 % | |||||||||
| 3c301 | DL-methionine, technically pure | Additive compositionMethionine content: minimum 99 %Characterisation of the active substanceIUPAC name: 2-amino-4-(methylthio)butanoic acidCAS number: 59-51-8Chemical formula: C5H11NO2SAnalytical methodsFor the determination of methionine in the additives:Ion exchange chromatography coupled with post-column derivatisation and photometric or fluorescence detection (HPLC-UV/FD) - ISO/DIS 17180.For the determination of methionine in premixtures, compound feed, feed materials and water:Ion exchange chromatography coupled with post-column derivatisation and photometric detection (HPLC-UV) - Commission Regulation (EC) No 152/2009 (Annex III, F). | all animal species | 1. DL-methionine, technically pure can be also used via water for drinking.2. Declarations to be made on the labelling of the additive and premixtures: If the additive is administered via water for drinking protein excess should be avoided. | 12 June 2023 | ||||
| 3c302 | Sodium DL-methionine, liquid | Additive compositionDL-Methionine content: minimum 40 %Sodium: minimum 6,2 %Water: maximum 53,8 %Characterisation of the active substanceIUPAC name: 2-amino-4-(methylthio)butanoic acid sodium saltCAS number: 41863-30-3Chemical formula: (C5H11NO2S)NaAnalytical methodsFor the determination of methionine in the additives:Ion exchange chromatography coupled with post-column derivatisation and photometric or fluorescence detection (HPLC-UV/FD) - ISO/DIS 17180.For the determination of methionine in premixtures, compound feed, feed materials and water:Ion exchange chromatography coupled with post-column derivatisation and photometric detection (HPLC-UV) - Commission Regulation (EC) No 152/2009 (Annex III, F). | all animal species | 1. For user safety: breathing protection, safety glasses and gloves should be worn during handling.2. Sodium DL-methionine, liquid can be also used via water for drinking.3. Declarations to be made on the labelling of the additive and premixtures: DL-Methionine content,If the additive is administered via water for drinking protein excess should be avoided. | 12 June 2023 | ||||
| 3c303 | DL-methionine protected with copolymer vinylpyridine/styrene | Additive compositionPreparation withDL-Methionine: minimum 74 %Stearic acid: maximum of 19 %Copolymer poly(2-vinylpyridine) co-styrene: maximum 3 %Ethylcellulose and sodium stearate: maximum 0,5 %Characterisation of the active substanceIUPAC name: 2-amino-4-(methylthio)butanoic acidCAS number: 59-51-8Chemical formula: C5H11NO2SAnalytical methodsFor the determination of methionine in the additives:Ion exchange chromatography coupled with post-column derivatisation and photometric or fluorescence detection (HPLC-UV/FD) - ISO/DIS 17180.For the determination of methionine in premixtures, compound feed and feed materials:Ion exchange chromatography coupled with post-column derivatisation and photometric detection (HPLC-UV) - Commission Regulation (EC) No 152/2009 (Annex III, F). | Ruminants | 12 June 2023 | |||||
| 3c304 | DL-methionine protected with ethylcellulose | Additive compositionPreparation withDL-Methionine: minimum 85 %Ethylcellulose: maximum 4 %Starch: maximum 8 %Sodium aluminium silicate: maximum 1,5 %Sodium stearate: maximum 1 %Water: maximum 2 %Characterisation of the active substanceIUPAC name: 2-amino-4-(methylthio)butanoic acidCAS number: 59-51-8Chemical formula: C5H11NO2SAnalytical methodsFor the determination of methionine in the additives:Ion exchange chromatography coupled with post-column derivatisation and photometric or fluorescence detection (HPLC-UV/FD) - ISO/DIS 17180.For the determination of methionine in premixtures, compound feed and feed materials:Ion exchange chromatography coupled with post-column derivatisation and photometric detection (HPLC-UV) - Commission Regulation (EC) No 152/2009 (Annex III, F). | Ruminants | 12 June 2023 | |||||
| 3c307 | — | Hydroxy analogue of methionine | Additive compositionHydroxy analogue of methionine: minimum 88 %Water: maximum 12 %Characterisation of the active substanceIUPAC name: 2-hydroxy-4-(methylthio)butanoic acidCAS number 583-91-5Chemical formula: C5H10O3SAnalytical methodsFor the determination of hydroxy analogue of methionine in the additive:Titrimetry, potentiometric titration followed by oxidation reduction reaction.For the determination of hydroxy analogue of methionine in premixtures, compound feed, feed materials and water:High-Performance Liquid Chromatography and photometric detection (HPLC-UV). | All animal species | — | — | — | 1. For user safety: breathing protection, safety glasses and gloves should be worn during handling.2. Hydroxy analogue of methionine can be also used via water for drinking.3. Declarations to be made on the labelling of the additive and premixtures: If the additive is administered via water for drinking protein excess should be avoided.4. Declarations to be made on the labelling of feed materials and compound feed in the listing of additives, if appropriate: Name of the additive,Amount of the hydroxy analogue of methionine added. | 12 June 2023 |
| 3c308 | — | Calcium salt of hydroxy analogue of methionine | Additive compositionHydroxy analogue of methionine: minimum 84 %Calcium: minimum 11,7 %Water: maximum 1 %Characterisation of the active substanceIUPAC name 2-hydroxy-4-(methylthio)butanoic acid, calcium saltCAS number 4857-44-7Chemical formula: (C5H9O3S)2CaAnalytical methodsFor the determination of hydroxy analogue of methionine in the additive:Titrimetry, potentiometric titration followed by oxidation reduction reaction.For the determination of hydroxy analogue of methionine in premixtures, compound feed and feed materials:High-Performance Liquid Chromatography and photometric detection (HPLC-UV). | All animal species | — | — | — | 1. For user safety: breathing protection, safety glasses and gloves should be worn during handling.2. Declarations to be made on the labelling of the additive and premixtures: Hydroxy analogue of methionine content.3. Declarations to be made on the labelling of feed materials and compound feed in the listing of additives, if appropriate: Name of the additive,Amount of the hydroxy analogue of methionine added. | 12 June 2023 |
| 3c309 | — | Isopropyl ester of hydroxy analogue of methionine | Additive compositionPreparation of isopropyl ester of hydroxy analogue of methionine: minimum 95 %Water: maximum 0,5 %Characterisation of the active substanceIUPAC name isopropyl ester of 2-hydroxy-4-(methylthio)butanoic acidCAS number 57296-04-5Chemical formula: C8H16O3SAnalytical methodFor the determination of isopropyl ester of the hydroxy analogue of methionine in the feed:High-Performance Liquid Chromatography and photometric detection (HPLC-UV). | Ruminants | — | — | — | 1. Declarations to be made on the labelling of the additive and premixtures: Content of hydroxy analogue of methionine2. Declarations to be made on the labelling of feed materials and compound feed in the listing of additives, if appropriate: Name of the additive,Amount of the hydroxy analogue of methionine added. | 12 June 2023 |
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