63In that connection, it is settled case-law that, having regard to the nature and structure of the TRIPs Agreement, the provisions of that agreement do not have direct effect. Thus, those provisions are not, in principle, among the rules in the light of which the Court is to review the legality of measures of the EU institutions and are not such as to create rights upon which individuals may rely directly before the courts by virtue of EU law (see, to that effect, judgments of 14 December 2000, Dior and Others, C‑300/98 and C‑392/98, EU:C:2000:688, paragraphs 43 to 45; of 16 November 2004, Anheuser-Busch, C‑245/02, EU:C:2004:717, paragraph 54; and of 28 September 2023, Changmao Biochemical Engineering v Commission, C‑123/21 P, EU:C:2023:708, paragraphs 70 and 71).
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