69It is apparent from that presentation that the information requested from the registrants under Annexes VII to X, in particular the standard information in column 1 of those annexes, which must in all cases be provided except where such information may be adapted under a provision in column 2, is requested incrementally based on the manufactured or imported quantities of substance. It must also be pointed out that those information obligations concern chemical substances and are intended, as set out in Article 1 of the REACH Regulation, to ensure that the hazards associated with those substances, when manufactured, placed on the market and used, are known and that those substances, when used, do not adversely affect human health or the environment. Consequently, in the light of the potential hazards of chemical substances and applying the precautionary principle, but also taking into account the objective of preventing unnecessary testing on vertebrate animals, that principle and that objective both also being referred to in that article, the legislature has already made choices in order to request registrants to carry out studies on vertebrate animals only if those studies appear relevant in view of the relevant quantities of substance. Moreover, Annex XI also provides for possibilities of adaptation which are additional to those provided for in column 2 of Annexes VII to X, which the registrants may put forward if they consider that a study provided for in those annexes serves no purpose.