31By contrast, under the second paragraph of Article 288 TFEU, an EU regulation is to be directly applicable in all Member States. It is settled case-law that any national court, hearing a case within its jurisdiction, has, as an organ of a Member State, the obligation pursuant to the principle of cooperation set out in Article 4(3) TEU, fully to apply the directly applicable law of the Union and to protect the rights which the latter confers upon individuals, disapplying any provision of national law which may be to the contrary, whether the latter is prior to or subsequent to the EU legal rule (judgment of 8 September 2010, Winner Wetten, C‑409/06, EU:C:2010:503, paragraph 55).
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