50In that respect, according to the case-law, a distinction must, as a general rule, be drawn between the review that the EU judicature may be called upon to carry out, on the one hand, of the formal legality of the CHMP’s scientific opinion and, on the other hand, the Commission’s exercise of its discretion (see, to that effect, judgments of 7 March 2013, Acino v Commission, T‑539/10, not published, EU:T:2013:110, paragraph 92, and of 11 December 2014, PP Nature-Balance Lizenz v Commission, T‑189/13, not published, EU:T:2014:1056, paragraph 33; see also, to that effect and by analogy, judgment of 26 November 2002, Artegodan v Commission, T‑74/00, T‑76/00, T‑83/00 to T‑85/00, T‑132/00, T‑137/00 and T‑141/00, EU:T:2002:283, paragraph 199).