166Where the Commission comes to such a conclusion, it should, in accordance with Article 21(3) of Regulation No 1107/2009, adopt a regulation withdrawing or amending the approval of the active substance concerned. Thus, by providing for the withdrawal or amendment of that approval, that provision expressly incorporates the principle of proportionality which, according to settled case-law, is one of the general principles of EU law and requires that acts of the EU institutions should not exceed the limits of what is appropriate and necessary to achieve the legitimate objectives pursued by the rules in question, it being understood that, where there is a choice between several appropriate measures, the least restrictive should be used and that the negative consequences must not be disproportionate to the aims pursued (judgment of 8 July 2010, Afton Chemical, C‑343/09, EU:C:2010:419, paragraph 45 and the case-law cited).
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