49As regards the ability of an agreement, decision or concerted practice extending over the whole of the territory of a Member State to affect trade between Member States, it is settled case-law that such an agreement, decision or concerted practice has, by its very nature, the effect of reinforcing the partitioning of markets on a national basis, thereby holding up the economic interpenetration which the FEU Treaty is designed to bring about (see judgments in Vereeniging van Cementhandelaren v Commission, 8/72, EU:C:1972:84, paragraph 29; Commission v Italy, C‑35/96, EU:C:1998:303, paragraph 48; and Wouters and Others, C‑309/99, EU:C:2002:98, paragraph 95).
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