48In that regard, it should be recalled that the absence of a handwritten signature on the application by a lawyer entitled to sign is not among the formal irregularities that are capable of being cured in accordance with the second paragraph of Article 21 of the Statute of the Court of Justice, Article 44(6) of the Rules of Procedure of the Court of First Instance and Article 6(1), (4) and (5) of the Instructions to the Registrar of the Court of First Instance.